South Carolina Prescription Pads

In addition to the federal requirements, South Carolina state law requires that a written prescription for any Schedule II, III, IV, and V controlled substance must be written on tamper-resistant prescription pads which contain one or more industry-recognized features designed to prevent all of the following:

• unauthorized copying of a completed or blank prescription form;
• erasure or modification of information written on the prescription by the prescriber; and
• use of counterfeit prescription forms.

Also, a written prescription must have two signature lines at opposite ends on the bottom of the form. Under the line at the left side must be clearly printed the words "DISPENSE AS WRITTEN". Under the line at the right side shall be clearly printed the words "SUBSTITUTION PERMITTED", unless the prescription is to be paid for with Medicaid funds. The practitioner shall communicate the instructions to the pharmacist by signing on the appropriate line. A written prescription is not valid without the signature of the practitioner on one of these lines.

Read documentation here and here, the latter under section 39-24-40.

For the federal requirements, you can refer to the official documentation here and here.